Breakthrough Research: Sestrins Can Supplement Exercise and Deliver Results

  • Sestrins research was done at the University of Michigan.
  • Sestrins prevent atrophy.
  • It could be a breakthrough to shortening rehabilitation time.

A new study has been published claiming that Sestrins are evolutionarily conserved mediators of exercise benefits. It could be possible to enjoy the benefits of exercise without actually doing it. However, exercise is important for cardiovascular health and even from a psychological prospective.

A lot of times people get injured during exercise, or due to aging, many types of sports activities become not possible. The researchers from Michigan university believe it may be possible to achieve the benefits of exercise without doing so. Is it far fetched? No, according to the researchers, while studying sestrins. The Sestrins constitute a family of evolutionarily-conserved stress-inducible proteins that suppress oxidative stress and regulate adenosine monophosphate-dependent protein kinase (AMPK)-mammalian target of rapamycin (mTOR) signaling.

During the research it was discovered sestrins could be a substitute to physical activity. The study was first conducted using fruit flies. The authors of the study explain that in the laboratories, Drosophila was constantly trying to climb the walls of the containers or fly out of them. Therefore, experts developed a “simulator” for their research. It was a container that shook flies to the bottom every 15 seconds. Insects were forced again and again to climb up or take off. The researchers trained three different groups of flies.  Insects from the first group were unable to produce sestrins. In Drosophila from the second group, on the contrary, increased the expression of this protein. The third group was a control group.

The researchers from Michigan university believe it may be possible to achieve the benefits of exercise without doing so.

After three weeks, the researchers were able to evaluate the ability of insects to crawl and fly over long periods of time. It turned out that the endurance of the experimental group from the control group improved, but the flies unable to produce sestrins did not. Meanwhile, Drosophila who produced more of this protein than usual were most likely to become champions. It means that the protein enhances physical capabilities, not just stamina alone.

Additional experiments showed that in mice unable to produce sestrins fat is not burned during training, and respiration and aerobic ability do not improve (it depends on the amount of oxygen that the body is able to process while in a state of physical activity). In other words, if the body does not produce sestrin, exercise will not be beneficial.

Another study by Spanish researchers showed that sestrin prevents muscle atrophy during a bed ridden stage. It is very important for bed injured patients with severe injuries who will be lying down for a long period of time.  In the future, researchers plan to closely study the impact of sestrin on the human body. The goal is to have food additives in the future that could be used to supplement exercise.  Overall, it would be a great addition for the physiotherapists and additional treatment during the rehabilitation process. Yet, it would still be important to have physical exercise, not just the use of the supplements. Nevertheless, it is important research and it could be a breakthrough discovery and shorten the duration of the rehabilitation.

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Christina Kitova

I spent most of my professional life in finance, insurance risk management litigation.

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